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Simultaneous acquisition of gradient echo/spin echo BOLD and perfusion with a separate labeling coil
Author(s) -
Glielmi C. B.,
Xu Q.,
Craddock R. C.,
Hu X.
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22554
Subject(s) - echo (communications protocol) , spin echo , cerebral blood flow , nuclear magnetic resonance , gradient echo , arterial spin labeling , reproducibility , pulse sequence , magnetic resonance imaging , site directed spin labeling , chemistry , physics , medicine , computer science , radiology , cardiology , computer network , chromatography , electron paramagnetic resonance
Arterial spin labeling‐based cerebral blood flow imaging complements blood oxygenation level dependent (BOLD) imaging with a measure that is more quantitative and has better specificity to neuronal activation. Relative to gradient echo BOLD, spin echo BOLD has better spatial specificity because it is less biased to large draining veins. Although there have been many studies comparing simultaneously acquired cerebral blood flow data with gradient echo BOLD data in fMRI, there have been few studies comparing cerebral blood flow with SE BOLD and no study comparing all three. We present a pulse sequence that simultaneously acquires cerebral blood flow data with a separate labeling coil, gradient echo BOLD, and spin echo BOLD images. Simultaneous acquisition avoids interscan variability, allowing more direct assessment and comparison of each contrast's relative specificity and reproducibility. Furthermore, it facilitates studies that may benefit from multiple complementary measures. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.