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Rapid T 1 mapping of mouse myocardium with saturation recovery look‐locker method
Author(s) -
Li Wen,
Griswold Mark,
Yu Xin
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22544
Subject(s) - saturation (graph theory) , nuclear magnetic resonance , computer science , mathematics , physics , combinatorics
Dynamic contrast‐enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look‐Locker method was developed and validated for fast cardiac T 1 mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal resolution (∼3 min) can be achieved at a high spatial resolution (195 × 390 μm2) in mouse heart without the aid of parallel imaging or echo‐planar imaging. Validation studies were performed both in vitro on a phantom and in vivo on C57BL/6 mice ( n = 6). Our results showed a strong agreement between T 1 measured by saturation recovery Look‐Locker and by the standard saturation recovery method in vitro or inversion recovery Look‐Locker in vivo. The utility of saturation recovery Look‐Locker in dynamic contrast‐enhanced MRI studies was demonstrated in manganese‐enhanced MRI experiments in mice. Our results suggest that saturation recovery Look‐Locker can provide rapid and accurate cardiac T 1 mapping for studies using small animal models. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.