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23 Na and 2 H magnetic resonance studies of osteoarthritic and osteoporotic articular cartilage
Author(s) -
KeinanAdamsky Keren,
Shinar Haddasah,
Shabat Shay,
Brin Yaron S.,
Nyska Meir,
Navon Gil
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22479
Subject(s) - osteoarthritis , cartilage , bone decalcification , osteoporosis , chemistry , articular cartilage , magnetic resonance imaging , proteoglycan , sodium , osteoporotic fracture , nuclear magnetic resonance , medicine , anatomy , bone mineral , pathology , radiology , physics , alternative medicine , organic chemistry
In this study, the short component of the 23 Na T 2 (T 2f ) and the 23 Na and 2 H quadrupolar interactions (ν Q ) were measured in bone‐cartilage samples of osteoarthritic (OA) and osteoporotic (OP) patients. 23 Na ν Q was found to increase in osteoarthritic articular cartilage relative to controls. Similar results were found in bovine cartilage following proteoglycan (PG) depletion, a condition that prevails in osteoarthritis. 23 Na ν Q and 1/ T 2f for articular cartilage obtained from osteoporotic patients were significantly larger than for control and osteoarthritic cartilage. Decalcification of both human and bovine articular cartilage resulted in an increase of 23 Na ν Q and 1/ T 2f , showing the same trend as the osteoporotic samples. Differences in the ratio of the intensity of the large 2 H splitting to that of the small one in the calcified zone were also observed. In osteoporosis, this ratio was twice as large as that obtained for both control and osteoarthritic samples. The 2 H and 23 Na results can be interpreted as due to sodium ions and water molecules filling the void created by the calcium depletion and to calcium ions being located in close association with the collagen fibers. To the best of our knowledge, this is the first study reporting differences of NMR parameters in cartilage of osteoporotic patients. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.