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Cardiac 17 O MRI: Toward direct quantification of myocardial oxygen consumption
Author(s) -
McCommis Kyle S.,
He Xiang,
Abendschein Dana R.,
Gupte Pradeep M.,
Gropler Robert J.,
Zheng Jie
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22382
Subject(s) - oxygen , chemistry , nuclear magnetic resonance , nuclear medicine , medicine , physics , organic chemistry
A new 17 O‐labeled blood contrast agent was injected intravenously in control dogs. Electrocardiogram (ECG)‐triggered myocardial T 1 ρ imaging was performed to obtain spin‐locking T 1 ρ‐weighted myocardial signals for the detection of resultant metabolite H 2 17 O water in the heart. Bolus and slow injection methods of various doses of the 17 O‐labeled and 16 O‐labeled agents were carried out in order to evaluate the sensitivity of this method and determine the optimal injection method. Bolus injection provided approximately 1% signal reduction, whereas slow injection with larger amount of agent yielded 11.9 ± 0.6% signal reduction. Myocardial oxygen consumption rate was determined by a technique to quantify cerebral oxygenation consumption rate previously developed in 17 O brain studies. With either injection method, myocardial oxygen consumption rate at rest was 5.0 – 5.6 μmol/g/min. Therefore, it appears feasible to detect metabolically generated H 2 17 O water in vivo in the heart, using the 17 O‐labeled blood tracer. Myocardial oxygen consumption rate can then be quantified in vivo, which may open new doors for the assessment of myocardial metabolism. Magn Reson Med 63:1442–1447, 2010. © 2010 Wiley‐Liss, Inc.