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Contrast agent influences MRI phase‐contrast flow measurements in small vessels
Author(s) -
Lagerstrand Kerstin M.,
VikhoffBaaz Barbro,
Starck Göran,
ForssellAronsson Eva
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22368
Subject(s) - contrast (vision) , blood flow , phase contrast microscopy , partial volume , flow (mathematics) , magnetic resonance angiography , angiography , biomedical engineering , magnetic resonance imaging , nuclear medicine , medicine , radiology , computer science , physics , optics , artificial intelligence , mechanics
Contrast‐enhanced MR angiography is often combined with phase contrast (PC) flow measurement to answer a particular clinical question. The contrast agent that is administered during contrast‐enhanced MR angiography may still be present in the blood during the consecutive PC flow measurement. The aim of this work was to evaluate the influence of contrast agent on PC flow measurements in small vessels. For that purpose, both in vivo measurements and computer simulations were performed. The dependence of the PC flow quantification on the signal amplitude difference between blood and stationary background tissue for various vessel sizes was characterized. Results show that the partial‐volume effect strongly affects the accuracy of the PC flow quantification when the imaged vessel is small compared to the spatial resolution. A higher blood‐to‐background‐contrast level during imaging significantly increases the partial‐volume effect and thereby reduces the accuracy of the flow quantification. On the other hand, a higher blood‐to‐background‐contrast level facilitated the segmentation of the vessel for flow rate determination. PC flow measurements should therefore be performed after contrast agent administration in large vessels, but before contrast agent administration in small vessels. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.