Premium
Comparative SNR for high‐throughput mouse embryo MR microscopy
Author(s) -
Zhang Xiaoli,
Schneider Jurgen E.,
Portnoy Sharon,
Bhattacharya Shoumo,
Henkelman R. Mark
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22352
Subject(s) - embryo , throughput , microscopy , signal to noise ratio (imaging) , isotropy , high resolution , high throughput screening , biology , computer science , physics , microbiology and biotechnology , bioinformatics , optics , telecommunications , wireless , remote sensing , geology
MR microscopy is being explored as a useful imaging tool to phenotype mouse embryos due to its volume coverage with three‐dimensional isotropic resolution. However, the main limitation for mouse embryo MR microscopy is the signal‐to‐noise ratio. Large numbers of embryos are needed for phenotypic screening, making high throughput essential. Two high‐throughput imaging approaches, multi‐embryo shared‐coil (shared) and multi‐embryo individual‐coil (individual), have been developed for phenotyping mouse embryos. This study quantitatively compares the signal‐to‐noise ratio at equivalent times between these two established methods by compensating for differences that result from field strength. While the individual method provides 3.3 times as much signal‐to‐noise ratio as the shared method at equivalent conditions, it is more difficult and expensive to implement. Furthermore, the number of embryos that can be imaged concurrently is limited by the number of receiver channels. The objective of this study is to provide measured comparative data to guide choices for high‐throughput mouse embryo MR microscopy and other similar applications. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.