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Quantitative 19 F imaging using inductively coupled reference signal injection
Author(s) -
Lee Donghoon,
Marro Kenneth,
Shankland Eric,
Mathis Mark
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22298
Subject(s) - metabolite , voxel , chemistry , sodium , signal (programming language) , nuclear magnetic resonance , physics , computer science , artificial intelligence , biochemistry , organic chemistry , programming language
This report describes recent efforts on our continuous development of a synthetic signal injection method for quantification of metabolite content in MR spectroscopy and MRI. Previous work showed that conversion of spectral peaks to quantitative units of metabolite content could be achieved with a calibrated synthetic free induction decay generated by an inductively coupled injection coil. This work demonstrates that calibrated synthetic voxels, injected in the same manner, can be used to quantify metabolite content in real 19 F image voxels. Images of vials containing different concentrations of sodium fluoride (NaF) were converted to units of moles by reference to precalibrated synthetically injected voxels. Additional images of vials containing variable sodium chloride (NaCl) demonstrate that the quantification process is robust and immune to changes in coil loading conditions. Magn Reson Med 63:570–573, 2010. © 2010 Wiley‐Liss, Inc.