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Myocardial fat quantification in humans: Evaluation by two‐point water‐fat imaging and localized proton spectroscopy
Author(s) -
Liu ChiaYing,
Redheuil Alban,
Ouwerkerk Ronald,
Lima Joao A. C.,
Bluemke David A.
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22289
Subject(s) - in vivo , in vivo magnetic resonance spectroscopy , nuclear medicine , chemistry , nuclear magnetic resonance , magnetic resonance imaging , epicardial fat , medicine , adipose tissue , radiology , biology , physics , microbiology and biotechnology
Proton MR spectroscopy ( 1 H‐MRS) has been used for in vivo quantification of intracellular triglycerides within the sarcolemma. The purpose of this study was to assess whether breath‐hold dual‐echo in‐ and out‐of‐phase MRI at 3.0 T can quantify the fat content of the myocardium. Biases, including T 1 , T * 2 , and noise, that confound the calculation of the fat fraction were carefully corrected. Thirty‐four of 46 participants had both MRI and MRS data. The fat fractions from MRI showed a strong correlation with fat fractions from MRS ( r = 0.78; P < 0.05). The mean myocardial fat fraction for all 34 subjects was 0.7 ± 0.5% (range: 0.11–3%) assessed with MRS and 1.04 ± 0.4% (range: 0.32–2.44%) assessed with in‐ and out‐of‐phase MRI ( P < 0.05). Scanning times were less than 15 sec for Dixon imaging, plus an additional minute for the acquisition used for T * 2 calculation, and 15‐20 min for MRS. The average postprocessing time for MRS was 3 min and 5 min for MRI including T * 2 measurement. We conclude that the dual echo method provides a rapid means to detect and quantifying myocardial fat content in vivo. Correction/adjustment for field inhomogeneity using three or more echoes seems crucial for the dual echo approach. Magn Reson Med 63:892–901, 2010. © 2010 Wiley‐Liss, Inc.