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Brain metabolites B 1 ‐corrected proton T 1 mapping in the rhesus macaque at 3 T
Author(s) -
Liu Songtao,
Fleysher Roman,
Fleysher Lazar,
Joo ChanGyu,
Ratai EvaMaria,
González R. Gilberto,
Gonen Oded
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22270
Subject(s) - creatine , choline , in vivo magnetic resonance spectroscopy , white matter , nuclear magnetic resonance , voxel , nuclear medicine , nuclear magnetic resonance spectroscopy , chemistry , physics , magnetic resonance imaging , medicine , radiology , biochemistry
The accuracy of metabolic quantification in MR spectroscopy is limited by the unknown radiofrequency field and T 1 . To address both issues in proton ( 1 H) MR spectroscopy, we obtained radiofrequency field–corrected T 1 maps of N ‐acetylaspartate, choline, and creatine in five healthy rhesus macaques at 3 T. For efficient use of the 4 hour experiment, we used a new three‐point protocol that optimizes the precision of T 1 in three‐dimensional 1 H‐MR spectroscopy localization for extensive, ∼30%, brain coverage at 0.6 × 0.6 × 0.5 cm 3 = 180‐μL spatial resolution. The resulting mean T 1 s in 700 voxels were N ‐acetylaspartate = 1232 ± 44, creatine = 1238 ± 23 and choline = 1107 ± 56 ms (mean ± standard error of the mean). Their histograms from all 140 voxels in each animal were similar in position and shape, characterized by standard errors of the mean of the full width at half maximum divided by their means of better than 8%. Regional gray matter N ‐acetylaspartate, choline, and creatine T 1 s (1333 ± 43, 1265 ± 52, and 1131 ± 28 ms) were 5–10% longer than white matter: 1188 ± 34, 1201 ± 24, and 1082 ± 50 ms (statistically significant for the N ‐acetylaspartate only), all within 10% of the corresponding published values in the human brain. Magn Reson Med 63:865–871, 2010. © 2010 Wiley‐Liss, Inc.