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A new paradigm for high‐sensitivity 19 F magnetic resonance imaging of perfluorooctylbromide
Author(s) -
Giraudeau Céline,
Flament Julien,
Marty Benjamin,
Boumezbeur Fawzi,
Mériaux Sébastien,
Robic Caroline,
Port Marc,
Tsapis Nicolas,
Fattal Elias,
Giacomini Eric,
Lethimonnier Franck,
Le Bihan Denis,
Valette Julien
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22269
Subject(s) - pulse sequence , nuclear magnetic resonance , spin echo , magnetic resonance imaging , echo time , sequence (biology) , sensitivity (control systems) , physics , chemistry , materials science , medicine , radiology , biochemistry , electronic engineering , engineering
In the present work, the NMR properties of perfluorooctylbromide are revisited to derive a high‐sensitivity fluorine MRI strategy. It is shown that the harmful effects of J‐coupling can be eliminated by carefully choosing the bandwidth of the 180° pulses in a spin‐echo sequence. The T 2 of the CF 3 resonance of the molecule is measured using a multispin‐echo sequence and shown to dramatically depend on the interpulse delay. Following these observations, an optimized multispin‐echo imaging sequence is derived and compared with short TE/pulse repetition time gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the multispin‐echo sequence is promising for future applications, in particular for targeted contrast agents such as perfluorooctylbromide nanoparticles. Magn Reson Med 63:1119–1124, 2010. © 2010 Wiley‐Liss, Inc.