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Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd‐DTPA‐BMA
Author(s) -
Bucholz Elizabeth,
Ghaghada Ketan,
Qi Yi,
Mukundan Srinivasan,
Rockman Howard A.,
Johnson G. Allan
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22259
Subject(s) - ejection fraction , ventricle , stroke volume , cardiac function curve , cardiology , end systolic volume , medicine , end diastolic volume , diastole , cardiac output , nuclear medicine , blood pressure , hemodynamics , heart failure
MR microscopy has enormous potential for small‐animal cardiac imaging because it is capable of producing volumetric images at multiple time points to accurately measure cardiac function. MR has not been used as frequently as ultrasound to measure cardiac function in the small animal because the MR methods required relatively long scan times, limiting throughput. Here, we demonstrate four‐dimensional radial acquisition in conjunction with a liposomal blood pool agent to explore functional differences in three populations of mice: six C57BL/6J mice, six DBA/2J mice, and six DBA/2J CSQ+ mice, all with the same gestational age and approximately the same weight. Cardiovascular function was determined by measuring both left ventricular and right ventricular end diastolic volume, end systolic volume, stroke volume, and ejection fraction. Statistical significance was observed in end diastolic volume, end systolic volume, and ejection fraction for left ventricular measurements between all three populations of mice. No statistically significant difference was observed in stroke volume in either the left or right ventricle for any of the three populations of mice. This study shows that MRI is capable of efficient, high‐throughput, four‐dimensional cardiovascular phenotyping of the mouse. Magn Reson Med 63:979–987, 2010. © 2010 Wiley‐Liss, Inc.