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Helium‐3 MR q ‐space imaging with radial acquisition and iterative highly constrained back‐projection
Author(s) -
O'Halloran Rafael L.,
Holmes James H.,
Wu YuChien,
Alexander Andrew,
Fain Sean B.
Publication year - 2010
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22158
Subject(s) - imaging phantom , helium , nuclear medicine , projection (relational algebra) , flip angle , physics , nuclear magnetic resonance , magnetic resonance imaging , biomedical engineering , mathematics , computer science , algorithm , radiology , medicine , atomic physics
An undersampled diffusion‐weighted stack‐of‐stars acquisition is combined with iterative highly constrained back‐projection to perform hyperpolarized helium‐3 MR q ‐space imaging with combined regional correction of radiofrequency‐ and T 1 ‐related signal loss in a single breath‐held scan. The technique is tested in computer simulations and phantom experiments and demonstrated in a healthy human volunteer with whole‐lung coverage in a 13‐sec breath‐hold. Measures of lung microstructure at three different lung volumes are evaluated using inhaled gas volumes of 500 mL, 1000 mL, and 1500 mL to demonstrate feasibility. Phantom results demonstrate that the proposed technique is in agreement with theoretical values, as well as with a fully sampled two‐dimensional Cartesian acquisition. Results from the volunteer study demonstrate that the root mean squared diffusion distance increased significantly from the 500‐mL volume to the 1000‐mL volume. This technique represents the first demonstration of a spatially resolved hyperpolarized helium‐3 q ‐space imaging technique and shows promise for microstructural evaluation of lung disease in three dimensions. Magn Reson Med, 2010. © 2009 Wiley‐Liss, Inc.