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4D retrospective black blood trueFISP imaging of mouse heart
Author(s) -
Miraux Sylvain,
Calmettes Guillaume,
Massot Philippe,
Lefrançois William,
Parzy Elodie,
Muller Bernard,
Arsac Laurent M.,
DeschodtArsac Véronique,
Franconi JeanMichel,
Diolez Philippe,
Thiaudière Eric
Publication year - 2009
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22139
Subject(s) - cardiac cycle , magnetic resonance imaging , nuclear medicine , pulse sequence , diastole , contrast to noise ratio , nuclear magnetic resonance , medicine , image quality , radiology , physics , computer science , artificial intelligence , blood pressure , image (mathematics)
The purpose of this study was to demonstrate the feasibility of steady‐state True fast imaging with steady precession (TrueFISP) four‐dimensional imaging of mouse heart at high resolution and its efficiency for cardiac volumetry. Three‐dimensional cine‐imaging of control and hypoxic mice was carried out at 4.7 T without magnetization preparation or ECG‐triggering. The k ‐space lines were acquired with the TrueFISP sequence (pulse repetition time/echo time = 4/2 ms) in a repeated sequential manner. Retrospective reordering of raw data allowed the reconstruction of 10 three‐dimensional images per cardiac cycle. The acquisition scheme used an alternating radiofrequency phase and sum‐of‐square reconstruction method. Black‐blood three‐dimensional images at around 200 μm resolution were produced without banding artifact throughout the cardiac cycle. High contrast to noise made it possible to estimate cavity volumes during diastole and systole. Right and left ventricular stroke volume was significantly higher in hypoxic mice vs controls (20.2 ± 2 vs 15.1 ± 2; P < 0.05, 24.9 ± 2 vs 20.4 ± 2; P < 0.05, respectively). In conclusion, four‐dimensional black‐blood TrueFISP imaging in living mice is a method of choice to investigate cardiac abnormalities in mouse models. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.