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Quantitative spectroscopic imaging with in situ measurements of tissue water T 1 , T 2 , and density
Author(s) -
Gasparovic C.,
Neeb H.,
Feis D.L.,
Damaraju E.,
Chen H.,
Doty M.J.,
South D.M.,
Mullins P.G.,
Bockholt H.J.,
Shah N.J.
Publication year - 2009
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22060
Subject(s) - voxel , nuclear magnetic resonance , proton , t2 relaxation , relaxation (psychology) , echo time , partial volume , signal (programming language) , magnetic resonance imaging , nuclear medicine , physics , chemistry , materials science , computer science , radiology , medicine , artificial intelligence , quantum mechanics , programming language
The use of tissue water as a concentration standard in proton magnetic resonance spectroscopy ( 1 H‐MRS) of the brain requires that the water proton signal be adjusted for relaxation and partial volume effects. While single voxel 1 H‐MRS studies have often included measurements of water proton T 1 , T 2 , and density based on additional 1 H‐MRS acquisitions (e.g., at multiple echo or repetition times), this approach is not practical for 1 H‐MRS imaging ( 1 H‐MRSI). In this report we demonstrate a method for using in situ measurements of water T 1 , T 2 , and density to calculate metabolite concentrations from 1 H‐MRSI data. The relaxation and density data are coregistered with the 1 H‐MRSI data and provide detailed information on the water signal appropriate to the individual subject and tissue region. We present data from both healthy subjects and a subject with brain lesions, underscoring the importance of water parameter measurements on a subject‐by‐subject and voxel‐by‐voxel basis. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.