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MR elastography as a method for the assessment of myocardial stiffness: Comparison with an established pressure–volume model in a left ventricular model of the heart
Author(s) -
Kolipaka Arunark,
McGee Kiaran P.,
Araoz Philip A.,
Glaser Kevin J.,
Manduca Armando,
Romano Anthony J.,
Ehman Richard L.
Publication year - 2009
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21991
Subject(s) - magnetic resonance elastography , imaging phantom , elastography , materials science , volume (thermodynamics) , stiffness , biomedical engineering , silicone rubber , nuclear magnetic resonance , nuclear medicine , physics , composite material , ultrasound , acoustics , medicine , thermodynamics
Abstract Magnetic resonance elastography (MRE) measurements of shear stiffness (μ) in a spherical phantom experiencing both static and cyclic pressure variations were compared to those derived from an established pressure–volume (P‐V)‐based model. A spherical phantom was constructed using a silicone rubber composite of 10 cm inner diameter and 1.3 cm thickness. A gradient echo MRE sequence was used to determine μ within the phantom at static and cyclic pressures ranging from 55 to 90 mmHg. Average values of μ using MRE were obtained within a region of interest and were compared to the P‐V‐derived estimates. Under both static and cyclic pressure conditions, the P‐V‐ and MRE‐based estimates of μ ranged from 98.2 to 155.1 kPa and 96.2 to 150.8 kPa, respectively. Correlation coefficients (R 2 ) of 0.98 and 0.97 between the P‐V and MRE‐based estimates of shear stiffness measurements were obtained. For both static and cyclic pressures, MRE‐based measures of μ agree with those derived from a P‐V model, suggesting that MRE can be used as a new, noninvasive method of assessing μ in sphere‐like fluid‐filled organs such as the heart. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.