Premium
iDQC anisotropy map imaging for tumor tissue characterization in vivo
Author(s) -
Branca Rosa T.,
Chen Yuming M.,
Mouraviev Vladimir,
Galiana Gigi,
Jenista Elizabeth R.,
Kumar Challa,
Leuschner Carola,
Warren Warren S.
Publication year - 2009
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21925
Subject(s) - anisotropy , spins , superparamagnetism , nuclear magnetic resonance , in vivo , breast tumor , characterization (materials science) , magnetic resonance imaging , materials science , breast cancer , cancer , physics , optics , biology , medicine , nanotechnology , radiology , magnetic field , magnetization , condensed matter physics , genetics , microbiology and biotechnology , quantum mechanics
Abstract Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH‐conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.