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Long‐range diffusion of hyperpolarized 3 He in rats
Author(s) -
Rodríguez Ignacio,
PérezSánchez José Manuel,
PecesBarba Germán,
Kaulisch Thomas,
Stiller Detlef,
RuizCabello Jesús
Publication year - 2009
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21826
Subject(s) - diffusion , nuclear magnetic resonance , effective diffusion coefficient , thermal diffusivity , chemistry , nuclear medicine , magnetic resonance imaging , medicine , physics , thermodynamics , radiology
Based on a stimulated‐echo technique, a method to construct an apparent diffusion coefficient (ADC) map of hyperpolarized 3 He in a long‐range diffusion scale is presented with a phase‐cycle alternative to remove all unwanted echoes. The approach was successfully applied to determine in vivo diffusion constants in rat lungs. The ADC values in healthy rats show a good agreement with reported values for diffusion times of ≈. These long diffusivity measurements may be sensitive to detect emphysema progression or tissue remodeling and thus have enormous potential for the diagnosis and tracking of disease progression and for drug evaluation. Magn Reson Med 61:54–58, 2009. © 2008 Wiley‐Liss, Inc.