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Magnetic field correlation as a measure of iron‐generated magnetic field inhomogeneities in the brain
Author(s) -
Jensen Jens H.,
Szulc Kamila,
Hu Caixia,
Ramani Anita,
Lu Hanzhang,
Xuan Liang,
Falangola Maria F.,
Chandra Ramesh,
Knopp Edmond A.,
Schenck John,
Zimmerman Earl A.,
Helpern Joseph A.
Publication year - 2009
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21823
Subject(s) - globus pallidus , basal ganglia , white matter , thalamus , nuclear magnetic resonance , correlation , human brain , magnetic resonance imaging , neuroscience , medicine , physics , psychology , central nervous system , mathematics , radiology , geometry
The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by nonheme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease. Magn Reson Med 61:481–485, 2009. © 2009 Wiley‐Liss, Inc.