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Field strength dependence of R 1 and R 2 * relaxivities of human whole blood to prohance, vasovist, and deoxyhemoglobin
Author(s) -
Blockley N.P.,
Jiang L.,
Gardener A.G.,
Ludman C.N.,
Francis S.T.,
Gowland P.A.
Publication year - 2008
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21792
Subject(s) - chemistry , monte carlo method , contrast (vision) , nuclear magnetic resonance , field strength , analytical chemistry (journal) , magnetic field , physics , mathematics , chromatography , statistics , quantum mechanics , optics
This study has measured the longitudinal and transverse (T 2 * ) relaxivity curves for ProHance (Gadoteridol), Vasovist (Gadofosveset) and deoxyhemoglobin at 1.5, 3.0, and 7.0 Tesla. The plots of R 1 versus both contrast agent and deoxyhemoglobin concentration were linear. The plots of R 2 *versus deoxyhemoglobin concentration showed a quadratic dependence. R 2 *versus contrast agent concentration showed a parabolic dependence with a minimum occurring at contrast agent concentrations of approximately 1.5 mM, corresponding to an accessible concentration in vivo. Monte Carlo simulations were performed to support the hypothesis that the minimum results from the susceptibility of the red blood cells being matched to the susceptibility of the plasma. Relaxivity values (s −1 mM −1 ) for R 2 *and R 1 for all agents and all three field strengths are given. Magn Reson Med 60:1313–1320, 2008. © 2008 Wiley‐Liss, Inc.