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Pharmacokinetic modeling of delayed gadolinium enhancement in the myocardium
Author(s) -
Knowles Benjamin R.,
Batchelor Philip G.,
Parish Victoria,
Ginks Matthew,
Plein Sven,
Razavi Reza,
Schaeffter Tobias
Publication year - 2008
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21767
Subject(s) - magnetic resonance imaging , compartment (ship) , contrast (vision) , myocardial infarction , distribution (mathematics) , kinetics , gadolinium , cardiomyopathy , pharmacokinetics , medicine , nuclear medicine , nuclear magnetic resonance , chemistry , cardiology , radiology , heart failure , computer science , physics , mathematical analysis , oceanography , organic chemistry , quantum mechanics , artificial intelligence , geology , mathematics
Delayed contrast‐enhanced magnetic resonance imaging (DCE‐MRI) provides prognostic information by delineating regions of myocardial scar. The mechanism of this delayed enhancement in myocardial infarctions (MIs) is hypothesized to result from altered kinetics and changes in the volumes of distribution in the myocardium. Pharmacokinetic models with two and three compartments were fitted to the concentration‐time curves of dynamic contrast‐enhanced MRI data obtained from five patients with known MI. Furthermore, the parameter stability was investigated in simulations for the two different models. The transfer constants and volumes of distribution showed a good correlation with imaging findings on early and delayed contrast‐enhanced MRI. The two compartment model showed higher parameter stability. The three compartment model allows a more in‐depth quantification of myocardial scarring. These models have the potential to improve the diagnosis of myocardial pathologies involving scar, with differing kinetics and volumes of distribution such as infarction or cardiomyopathy. Magn Reson Med 60:1524–1530, 2008. © 2008 Wiley‐Liss, Inc.