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Reproducibility study of whole‐brain 1 H spectroscopic imaging with automated quantification
Author(s) -
Gu Meng,
Kim DongHyun,
Mayer Dirk,
Sullivan Edith V.,
Pfefferbaum Adolf,
Spielman Daniel M.
Publication year - 2008
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21713
Subject(s) - reproducibility , voxel , magnetic resonance spectroscopic imaging , nuclear magnetic resonance , imaging phantom , signal (programming language) , signal to noise ratio (imaging) , radiofrequency coil , nuclear medicine , chemistry , magnetic resonance imaging , computer science , physics , artificial intelligence , optics , medicine , radiology , chromatography , programming language
A reproducibility study of proton MR spectroscopic imaging ( 1 H‐MRSI) of the human brain was conducted to evaluate the reliability of an automated 3D in vivo spectroscopic imaging acquisition and associated quantification algorithm. A PRESS‐based pulse sequence was implemented using dualband spectral‐spatial RF pulses designed to fully excite the singlet resonances of choline (Cho), creatine (Cre), and N ‐acetyl aspartate (NAA) while simultaneously suppressing water and lipids; 1% of the water signal was left to be used as a reference signal for robust data processing, and additional lipid suppression was obtained using adiabatic inversion recovery. Spiral k ‐space trajectories were used for fast spectral and spatial encoding yielding high‐quality spectra from 1 cc voxels throughout the brain with a 13‐min acquisition time. Data were acquired with an 8‐channel phased‐array coil and optimal signal‐to‐noise ratio (SNR) for the combined signals was achieved using a weighting based on the residual water signal. Automated quantification of the spectrum of each voxel was performed using LCModel. The complete study consisted of eight healthy adult subjects to assess intersubject variations and two subjects scanned six times each to assess intrasubject variations. The results demonstrate that reproducible whole‐brain 1 H‐MRSI data can be robustly obtained with the proposed methods. Magn Reson Med 60:542–547, 2008. © 2008 Wiley‐Liss, Inc.