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Regional metabolite T 2 in the healthy rhesus macaque brain at 7T
Author(s) -
Liu Songtao,
Gonen Oded,
Fleysher Lazar,
Fleysher Roman,
Soher Brian J.,
Pilkenton Sarah,
Lentz Margaret R.,
Ratai EvaMaria,
González R. Gilberto
Publication year - 2008
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21574
Subject(s) - rhesus macaque , macaque , creatine , white matter , nuclear magnetic resonance , choline , voxel , physics , chemistry , magnetic resonance imaging , nuclear medicine , neuroscience , biology , medicine , biochemistry , radiology , immunology
Although the rhesus macaque brain is an excellent model system for the study of neurological diseases and their responses to treatment, its small size requires much higher spatial resolution, motivating use of ultra‐high‐field ( B 0 ) imagers. Their weaker radio‐frequency fields, however, dictate longer pulses; hence longer TE localization sequences. Due to the shorter transverse relaxation time ( T 2 ) at higher B 0 s, these longer TEs subject metabolites to T 2 ‐weighting, that decrease their quantification accuracy. To address this we measured the T 2 s of N ‐acetylaspartate (NAA), choline (Cho), and creatine (Cr) in several gray matter (GM) and white matter (WM) regions of four healthy rhesus macaques at 7T using three‐dimensional (3D) proton MR spectroscopic imaging at (0.4 cm) 3 = 64 μl spatial resolution. The results show that macaque T 2 s are in good agreement with those reported in humans at 7T: 169 ± 2.3 ms for NAA (mean ± SEM), 114 ± 1.9 ms for Cr, and 128 ± 2.4 ms for Cho, with no significant differences between GM and WM. The T 2 histograms from 320 voxels in each animal for NAA, Cr, and Cho were similar in position and shape, indicating that they are potentially characteristic of “healthy” in this species. Magn Reson Med 59:1165–1169, 2008. © 2008 Wiley‐Liss, Inc.