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Effect of Gd‐DTPA induCED susceptibility on single‐point dixon fat/water separation
Author(s) -
Hoory Tamar,
Ramsay Elizabeth,
Plewes Donald B.
Publication year - 2008
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21569
Subject(s) - lesion , nuclear medicine , imaging phantom , nuclear magnetic resonance , magnetic resonance imaging , breast mri , chemistry , materials science , medicine , radiology , physics , mammography , pathology , breast cancer , cancer
A single‐point Dixon (SPD) fat/water separation method is proposed for breast dynamic contrast‐enhanced MRI (DCE‐MRI) in which field inhomogeneities and phase offsets measured prior to the injection of gadopentate dimeglumine (Gd‐DTPA) are used to correct the postinjection images. A breast phantom study was conducted to demonstrate this technique, in which varying excess concentrations of Gd‐DTPA (0–3 mM) were introduced into a 25‐cm 3 breast lesion. The presence of excess Gd‐DTPA in the lesion was found to create magnetic field perturbations of up to 0.35 μT per mM excess Gd‐DTPA around the lesion. However, these perturbations had a negligible effect on the quality of the fat/water separation for Gd‐DTPA concentrations in the range of, and exceeding, those observed in breast tumors following a standard 0.1 mmole/kg injection. Therefore, we conclude that the preinjection phase data is adequate for the correction of the postinjection images in breast exams. Magn Reson Med, 2008. © 2008 Wiley‐Liss, Inc.