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Interleaved narrow‐band PRESS sequence with adiabatic spatial‐spectral refocusing pulses for 1 H MRSI at 7T
Author(s) -
Balchandani Priti,
Pauly John,
Spielman Daniel
Publication year - 2008
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21539
Subject(s) - magnetic resonance spectroscopic imaging , nuclear magnetic resonance , adiabatic process , spectral resolution , physics , spectral line , creatine , chemistry , atomic physics , magnetic resonance imaging , medicine , biochemistry , astronomy , radiology , thermodynamics
Proton magnetic resonance spectroscopic imaging ( 1 H MRSI) is a useful technique for measuring metabolite levels in vivo, with Choline (Cho), Creatine (Cre), and N ‐Acetyl‐Aspartate (NAA) being the most prominent MRS‐detectable brain biochemicals. 1 H MRSI at very high fields, such as 7T, offers the advantages of higher SNR and improved spectral resolution. However, major technical challenges associated with high‐field systems, such as increased B 1 and B 0 inhomogeneity as well as chemical shift localization (CSL) error, degrade the performance of conventional 1 H MRSI sequences. To address these problems, we have developed a Position Resolved Spectroscopy (PRESS) sequence with adiabatic spatial‐spectral (SPSP) refocusing pulses, to acquire multiple narrow spectral bands in an interleaved fashion. The adiabatic SPSP pulses provide magnetization profiles that are largely invariant over the 40% B 1 variation measured across the brain at 7T. Additionally, there is negligible CSL error since the transmit frequency is separately adjusted for each spectral band. in vivo 1 H MRSI data were obtained from the brain of a normal volunteer using a standard PRESS sequence and the interleaved narrow‐band PRESS sequence with adiabatic refocusing pulses. In comparison with conventional PRESS, this new approach generated high‐quality spectra from an appreciably larger region of interest and achieved higher overall SNR. Magn Reson Med 59:973–979, 2008. © 2008 Wiley‐Liss, Inc.