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Tracer kinetic model–driven registration for dynamic contrast‐enhanced MRI time‐series data
Author(s) -
Buonaccorsi Giovanni A.,
O'Connor James P.B.,
Caunce Angela,
Roberts Caleb,
Cheung Sue,
Watson Yvonne,
Davies Karen,
Hope Lynn,
Jackson Alan,
Jayson Gordon C.,
Parker Geoffrey J.M.
Publication year - 2007
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21405
Subject(s) - voxel , computer science , artificial intelligence , computer vision , contrast (vision) , image registration , similarity (geometry) , imaging phantom , transformation (genetics) , dynamic contrast enhanced mri , partial volume , motion (physics) , magnetic resonance imaging , nuclear medicine , radiology , image (mathematics) , medicine , biochemistry , chemistry , gene
Dynamic contrast‐enhanced MRI (DCE‐MRI) time series data are subject to unavoidable physiological motion during acquisition (e.g., due to breathing) and this motion causes significant errors when fitting tracer kinetic models to the data, particularly with voxel‐by‐voxel fitting approaches. Motion correction is problematic, as contrast enhancement introduces new features into postcontrast images and conventional registration similarity measures cannot fully account for the increased image information content. A methodology is presented for tracer kinetic model–driven registration that addresses these problems by explicitly including a model of contrast enhancement in the registration process. The iterative registration procedure is focused on a tumor volume of interest (VOI), employing a three‐dimensional (3D) translational transformation that follows only tumor motion. The implementation accurately removes motion corruption in a DCE‐MRI software phantom and it is able to reduce model fitting errors and improve localization in 3D parameter maps in patient data sets that were selected for significant motion problems. Sufficient improvement was observed in the modeling results to salvage clinical trial DCE‐MRI data sets that would otherwise have to be rejected due to motion corruption. Magn Reson Med 58:1010–1019, 2007. © 2007 Wiley‐Liss, Inc.