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MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo
Author(s) -
Vinogradov Elena,
He Huamei,
Lubag Angelo,
Balschi James A.,
Sherry A. Dean,
Lenkinski Robert E.
Publication year - 2007
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21393
Subject(s) - in vivo , nuclear magnetic resonance , chemistry , pulse sequence , magnetic resonance imaging , paramagnetism , spin echo , bolus (digestion) , medicine , radiology , physics , microbiology and biotechnology , quantum mechanics , biology
In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ‐16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA‐4AmC − in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal‐to‐noise ratio (SNR) levels. The lowest injected concentration of TmDOTA‐4AmC − , 200 μL of a 2‐mM stock solution (corresponds to ∼0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low‐amplitude RF trains can detect paramagnetic exchanging agents in vivo. Magn Reson Med 58:650–655, 2007. © 2007 Wiley‐Liss, Inc.