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Unique patterns of diffusion directionality in rat brain tumors revealed by high‐resolution diffusion tensor MRI
Author(s) -
Zhang Jiangyang,
van Zijl Peter C.M.,
Laterra John,
Salhotra Amandeep,
Lal Bachchu,
Mori Susumu,
Zhou Jinyuan
Publication year - 2007
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21371
Subject(s) - diffusion mri , fractional anisotropy , nuclear magnetic resonance , directionality , in vivo , high resolution , human brain , glioblastoma , pathology , magnetic resonance imaging , biology , medicine , neuroscience , physics , radiology , cancer research , microbiology and biotechnology , remote sensing , geology
Diffusion tensor imaging (DTI) is a new technique that uses the microscopic motion of water molecules to probe tissue 3D microstructures. In this study, high‐resolution DTI was performed on rats bearing intracranial 9L gliosarcoma, F98 glioma, and human glioblastoma. It was found that the tumors consisted of central zones with low diffusion anisotropy and peripheral structures (rim) with high diffusion anisotropy. In the rims, water diffusion directionality formed a circular pattern for the 9L and F98 tumors, and a radial pattern for the human glioblastoma xenografts. These well‐organized diffusion patterns appeared at an early stage postimplantation and continued to exist with tumor growth in all three models. High‐resolution ex vivo imaging and histology confirmed the in vivo findings. These distinct patterns, undetectable with conventional MRI, may reflect tumor organization and growth patterns at the cellular level. Magn Reson Med 58:454–462, 2007. © 2007 Wiley‐Liss, Inc.