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What levels of precision are achievable for quantification of perfusion and capillary permeability surface area product using ASL?
Author(s) -
Carr John P.,
Buckley David L.,
Tessier Jean,
Parker Geoff J.M.
Publication year - 2007
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21317
Subject(s) - perfusion , coefficient of variation , accuracy and precision , capillary action , perfusion scanning , systematic error , nuclear magnetic resonance , biological system , biomedical engineering , chemistry , materials science , physics , mathematics , statistics , chromatography , medicine , cardiology , composite material , biology
Abstract We examine the use of arterial spin labeling (ASL) in normal brains of rats and humans to measure perfusion ( F ) and capillary permeability surface area product ( PS ) using a previously described two‐compartment model. We investigate the experimental limits on F and PS quantification using simulations and experimental verification in rat brain at 9.4T. A sensitivity analysis on the two‐compartment model is presented to estimate optimal experimental inversion times (TIs) for F and PS quantification and indicate how sensitive the model would be to changes in F and PS . We present the expected error on flow‐sensitive alternating inversion recovery (FAIR)‐based F and PS measurements and quantify the precision with which these parameters could be estimated at various signal‐to‐noise ratios (SNRs). Perfusion was measured in four rat brains using FAIR ASL, and we conclude that perfusion could be quantified with an acceptable level of precision using this technique. However, we found that to measure PS with even a 100% coefficient of variation (CV) would require an SNR increase of approximately 2 orders of magnitude over our acquired data. We conclude that with current MR capabilities and with the experimental approach used in this study, acceptable levels of precision in the measurement of PS are not possible. Magn Reson Med 58:281–289, 2007. © 2007 Wiley‐Liss, Inc.