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2 H double quantum filtered (DQF) NMR spectroscopy of the nucleus pulposus tissues of the intervertebral disc
Author(s) -
Perea William,
Cannella Marco,
Yang Jun,
Vega Alexander J.,
Polenova Tatyana,
Marcolongo Michele
Publication year - 2007
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21231
Subject(s) - nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , spectroscopy , chemistry , intervertebral disc , nucleus , relaxation (psychology) , deuterium , physics , anatomy , atomic physics , biology , quantum mechanics , neuroscience , microbiology and biotechnology
Deuterium ( 2 H) double‐quantum filtered (DQF) NMR spectroscopy of nucleus pulposus (NP) tissues from human intervertebral discs is reported. The DQF spectral intensities, DQ build‐up rates, and DQF‐detected rotating‐frame spin‐lattice relaxation times are sensitive to the degree of hydration of the NP tissue, and display a monotonous correlation with age between 15 and 80 years. The implications of this work are that the changes in water dynamics as detected via DQF NMR spectroscopy may be used as a probe of tissue degeneration in NP, particularly in the early stages of degeneration to which most standard NMR methods are not sensitive. Magn Reson Med 57:990–999, 2007. © 2007 Wiley‐Liss, Inc.