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Confirming the existence of five peaks in 129 Xe rat head spectra
Author(s) -
Kershaw Jeff,
Nakamura Kazuhiro,
Kondoh Yasushi,
Wakai Atsushi,
Suzuki Nobuko,
Kanno Iwao
Publication year - 2007
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21186
Subject(s) - shim (computing) , spectral line , xenon , nuclear magnetic resonance , chemistry , physics , surgery , medicine , erectile dysfunction , organic chemistry , astronomy
A series of experiments were performed to investigate why two peaks (D and E) of the five dissolved phase peaks in hyperpolarized 129 Xe rat head spectra appeared inconsistently in previous work. Specifically, spectra were acquired under conditions of various shim states, anaesthetics, and arterial ligation. The shimming experiments showed that slice‐shimming can be used to improve resolution of the dissolved phase peaks, but even so, subtle changes in the shim state that may dramatically alter the shape of peak E remain poorly understood. Also, the inability to shim gas spaces and tissue simultaneously may explain why inconsistent chemical shift values have been reported in the literature. A possible solution for this problem is suggested. The results of pre‐ and postligation spectra from the same animal indicated that two peaks (A and E) originate from brain. Changing the anaesthetic was found to have no effect on the number of dissolved peaks in xenon spectra. Magn Reson Med 57:791–797, 2007. © 2007 Wiley‐Liss, Inc.