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Hyperpolarized 13 C MRI of the pulmonary vasculature and parenchyma
Author(s) -
Ishii Masaru,
Emami Kiarash,
Kadlecek Stephen,
Petersson J. Stefan,
Golman Klaes,
Vahdat Vahid,
Yu Jiangsheng,
Cadman Robert V.,
MacDuffieWoodburn John,
Stephen Michael,
Lipson David A.,
Rizi Rahim R.
Publication year - 2007
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21168
Subject(s) - perfusion , pulmonary vasculature , magnetic resonance imaging , perfusion scanning , parenchyma , lung , medicine , nuclear medicine , radiology , nuclear magnetic resonance , pathology , physics
The study of lung perfusion in normal and diseased subjects is of great interest to physiologists and physicians. In this work we demonstrate the application of a liquid‐phase hyperpolarized (HP) carbon‐13 ( 13 C) tracer to magnetic resonance imaging (MRI) of the pulmonary vasculature and pulmonary perfusion in a porcine model. Our results show that high spatial and temporal resolution images of pulmonary perfusion can be obtained with this contrast technique. Traditionally, pulmonary perfusion measurement techniques have been challenging because of insufficient signal for quantitative functional assessments. The use of polarized 13 C in MRI overcomes this limitation and may lead to a viable clinical method for studying the pulmonary vasculature and perfusion. Magn Reson Med 57:459–463, 2007. © 2007 Wiley‐Liss, Inc.