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Novel method for rapid, simultaneous T 1 , T * 2 , and proton density quantification
Author(s) -
Warntjes J.B.M.,
Dahlqvist O.,
Lundberg P.
Publication year - 2007
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21165
Subject(s) - voxel , proton , range (aeronautics) , nuclear magnetic resonance , physics , relaxation (psychology) , resolution (logic) , echo time , saturation (graph theory) , field (mathematics) , computational physics , materials science , mathematics , computer science , magnetic resonance imaging , nuclear physics , combinatorics , psychology , social psychology , artificial intelligence , pure mathematics , composite material , medicine , radiology
An imaging method called “quantification of relaxation times and proton density by twin‐echo saturation‐recovery turbo‐field echo” (QRAPTEST) is presented as a means of quickly determining the longitudinal T 1 and transverse T 2 *relaxation time and proton density (PD) within a single sequence. The method also includes an estimation of the B 1 field inhomogeneity. High‐resolution images covering large volumes can be achieved within clinically acceptable times of 5–10 min. The range of accuracy for determining T 1 , T 2 * , and PD values is flexible and can be optimized relative to any anticipated values. We validated the experimental results against existing methods, and provide a clinical example in which quantification of the whole brain using 1.5 mm 3 voxels was achieved in less than 8 min. Magn Reson Med 57:528–537, 2007. © 2007 Wiley‐Liss, Inc.
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