Premium
Experimentally‐derived functional form for a population‐averaged high‐temporal‐resolution arterial input function for dynamic contrast‐enhanced MRI
Author(s) -
Parker Geoff J.M.,
Roberts Caleb,
Macdonald Andrew,
Buonaccorsi Giovanni A.,
Cheung Sue,
Buckley David L.,
Jackson Alan,
Watson Yvonne,
Davies Karen,
Jayson Gordon C.
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21066
Subject(s) - gadodiamide , dynamic contrast , medicine , nuclear medicine , dynamic contrast enhanced mri , reproducibility , population , contrast (vision) , temporal resolution , bolus (digestion) , magnetic resonance imaging , radiology , artificial intelligence , mathematics , computer science , physics , statistics , environmental health , quantum mechanics
Rapid T 1 ‐weighted 3D spoiled gradient‐echo (GRE) data sets were acquired in the abdomen of 23 cancer patients during a total of 113 separate visits to allow dynamic contrast‐enhanced MRI (DCE‐MRI) analysis of tumor microvasculature. The arterial input function (AIF) was measured in each patient at each visit using an automated AIF extraction method following a standardized bolus administration of gadodiamide. The AIFs for each patient were combined to obtain a mean AIF that is representative for any individual. The functional form of this general AIF may be useful for studies in which AIF measurements are not possible. Improvements in the reproducibility of DCE‐MRI model parameters ( K trans , v e , and v p ) were observed when this new, high‐temporal‐resolution population AIF was used, indicating the potential for increased sensitivity to therapy‐induced change. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.