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T 2 * measurement during first‐pass contrast‐enhanced cardiac perfusion imaging
Author(s) -
Kellman Peter,
Aletras Anthony H.,
Hsu Liyueh,
McVeigh Elliot R.,
Arai Andrew E.
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21061
Subject(s) - perfusion , first pass , nuclear medicine , intensity (physics) , contrast (vision) , perfusion scanning , magnetic resonance imaging , medicine , nuclear magnetic resonance , cardiology , radiology , physics , mathematics , arithmetic , quantum mechanics , optics
Abstract First‐pass contrast‐enhanced (CE) myocardial perfusion imaging will experience T 2 *effects at peak concentrations of contrast agent. A reduction in the signal intensity of left ventricular (LV) blood due to T 2 *losses may effect estimates of the arterial input function (AIF) used for quantitative perfusion measurement. Imaging artifacts may also result from T 2 *losses as well as off‐resonance due to the bolus susceptibility. We hypothesized that T 2 *losses would not be significant for measurement of the AIF in full‐dose studies using a short echo time (TE = 0.6 ms). The purpose of this study was to directly measure T 2 *in the LV cavity during first‐pass perfusion. For single‐dose Gd‐DTPA (0.1 mmol/kg at 5 ml/s), the LV blood pool T 2 *had a mean value of 9 ms ( N = 10) at peak enhancement. Distortion of the AIF due to T 2 *signal intensity loss will be less than 10% using TE = 0.6 ms. Magn Reson Med, 2006. Published 2006 Wiley‐Liss, Inc.