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Localized short‐echo‐time proton MR spectroscopy with full signal‐intensity acquisition
Author(s) -
Mlynárik Vladimír,
Gambarota Giulio,
Frenkel Hanne,
Gruetter Rolf
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21043
Subject(s) - nuclear magnetic resonance , spin echo , pulse sequence , sensitivity (control systems) , physics , signal (programming language) , spectroscopy , echo time , magnetization , excitation , chemistry , magnetic resonance imaging , magnetic field , computer science , medicine , quantum mechanics , electronic engineering , engineering , radiology , programming language
We developed a short‐echo‐time (TE) sequence for proton localized spectroscopy by combining a 1D add‐subtract scheme with a doubly slice‐selective spin‐echo (SE) sequence. The sequence preserves the full magnetization available from the selected volume of interest (VOI). By reducing the number of radiofrequency (RF) pulses acting on transverse magnetization, we were able to minimize the TE to the level that is achievable with the stimulated echo acquisition mode (STEAM) technique, and also gained a twofold increase in sensitivity. The use of an adiabatic pulse in the add‐subtract localization improved the efficiency of excitation in spatially inhomogeneous RF fields, which are frequently encountered at high magnetic fields. The localization performance and sensitivity gains of this method, which is termed SPin ECho, full Intensity Acquired Localized (SPECIAL) spectroscopy, were demonstrated in vivo in rat brains. In conjunction with spectroscopic imaging, a 2‐μl spatial resolution was accomplished with a signal‐to‐noise ratio (SNR) above 30, which is usually sufficient for reliable quantification of a large number of metabolites (neurochemical profile). Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.