Premium
Contrast enhanced MRI‐guided photodynamic therapy for site‐specific cancer treatment
Author(s) -
Vaidya Anagha,
Sun Yongen,
Ke Tianyi,
Jeong EunKee,
Lu ZhengRong
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21009
Subject(s) - photodynamic therapy , conjugate , magnetic resonance imaging , photosensitizer , medicine , bifunctional , cancer , cancer research , chemistry , radiology , mathematical analysis , biochemistry , mathematics , organic chemistry , catalysis
Photodynamic therapy (PDT) is a minimally invasive and effective approach for cancer treatment. It is potentially useful for treating tumors that are not accessible to surgery, radiation, or destructive ablations, and are resistant to chemotherapy. Efficacious treatment of interstitial tumors with PDT requires efficient delivery of photosensitizers and accurate location of tumor tissues for effective light irradiations. In this study we performed contrast‐enhanced (CE) MRI‐guided PDT with a bifunctional polymer conjugate containing both a magnetic resonance imaging (MRI) contrast agent and a photosensitizer, poly( L ‐glutamic acid) (PGA)‐(Gd‐DO3A)‐mesochlorin e 6 (Mce 6 ). The efficacy of the bifunctional conjugate in cancer CE‐MRI and cancer treatment was evaluated in athymic nude mice bearing MDA‐MB‐231 human breast carcinoma xenografts, with PGA‐(Gd‐DO3A) used as a control. The polymer conjugates preferentially accumulated in the solid tumor due to the hyperpermeability of the tumor vasculature, resulting in significant tumor enhancement for accurate tumor detection and localization by MRI. Significant therapeutic response was observed for PDT with the bifunctional conjugate as compared to the control. CE‐MRI‐guided PDT with the bifunctional conjugate is effective for tumor detection and minimally invasive cancer treatment. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.