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Spatially localized intermolecular zero‐quantum coherence spectroscopy for in vivo applications
Author(s) -
Balla David Z.,
Melkus Gerd,
Faber Cornelius
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.21007
Subject(s) - spectroscopy , voxel , imaging phantom , nuclear magnetic resonance , coherence (philosophical gambling strategy) , spectral line , anisotropy , in vivo magnetic resonance spectroscopy , resolution (logic) , spectral resolution , physics , chemistry , dipole , optics , computational physics , magnetic resonance imaging , computer science , medicine , quantum mechanics , astronomy , artificial intelligence , radiology
Magnetic resonance spectroscopy (MRS) techniques that use the distant dipolar field (DDF) to locally refocus inhomogeneous line‐broadening promise improved spectral resolution in spatially varying fields. We investigated three possible implementations of localized DDF spectroscopy. Theoretical analysis and phantom experiments at 17.6 T showed that only localization immediately prior to acquisition provides sufficient spatial selectivity and sensitivity for in vivo applications. Spectra from an (8 mm) 3 voxel of the rat brain were acquired in 25 min, and three major metabolites were resolved. In a tumor mouse model, DDF spectra with well‐resolved lines can be obtained from significantly larger voxels compared to conventional localized spectroscopy. From an inhomogeneous voxel, improved spectral resolution can be obtained with DDF techniques when a sufficient number of increments are sampled along the second spectral dimension. With fewer increments, measurement time is significantly shortened, and DDF techniques can provide higher signal‐to‐noise ratio (SNR) efficiency. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.