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MR assessment of changes of tumor in response to hyperbaric oxygen treatment
Author(s) -
Matsumoto Kenichiro,
Bernardo Marcelino,
Subramanian Sankaran,
Choyke Peter,
Mitchell James B.,
Krishna Murali C.,
Lizak Martin J.
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20961
Subject(s) - hyperbaric oxygen , nuclear medicine , multislice , medicine , intensity (physics) , nuclear magnetic resonance , signal (programming language) , physics , surgery , computer science , optics , programming language
Enhancement of image intensity, using the T 1 ‐weighted spoiled gradient‐echo (SPGR) sequence, was measured in SCC tumor implanted in the flank of C3H mice while they were subjected to several types of oxygenation challenges inside a hyperbaric chamber designed and constructed to fit in an MRI resonator. The central portions of the tumor gave a positive enhancement, while the periphery showed signal reduction during both normobaric (NBO) and hyperbaric (HBO) oxygen challenges. In the contralateral normal leg, nearly 70% of the region showed a decrease in intensity, and the rest showed a positive enhancement. The positive signal enhancement was markedly greater under HBO compared to NBO. Calculated R 1 , R 2 , and M 0 maps from multivariate fitting of images acquired by a multislice multiecho (MSME) sequence with variable TR before, during, and after HBO treatment confirm that the source of SPGR signal enhancement in the tumor is associated with shortening of T 1 . Magn Reson Med, 2006. Published 2006 Wiley‐Liss, Inc.