Premium
Measurement of xenon diffusing capacity in the rat lung by hyperpolarized 129 Xe MRI and dynamic spectroscopy in a single breath‐hold
Author(s) -
Abdeen Nishard,
Cross Albert,
Cron Gregory,
White Steven,
Rand Thomas,
Miller David,
Santyr Giles
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20943
Subject(s) - xenon , diffusing capacity , chemistry , lung , pulmonary diffusing capacity , nuclear magnetic resonance , lung volumes , parenchyma , analytical chemistry (journal) , pathology , chromatography , medicine , physics , lung function , organic chemistry
We used the dual capability of hyperpolarized 129 Xe for spectroscopy and imaging to develop new measures of xenon diffusing capacity in the rat lung that (analogously to the diffusing capacity of carbon monoxide or D LCO ) are calculated as a product of total lung volume and gas transfer rate constants divided by the pressure gradient. Under conditions of known constant pressure breath‐hold, the volume is measured by hyperpolarized 129 Xe MRI, and the transfer rate is measured by dynamic spectroscopy. The new quantities (xenon diffusing capacity in lung parenchyma ( D LXeLP )), xenon diffusing capacity in RBCs ( D LXeRBC ), and total lung xenon diffusing capacity ( D LXe )) were measured in six normal rats and six rats with lung inflammation induced by instillation of fungal spores of Stachybotrys chartarum . D LXeLP , D LXeRBC , and D LXe were 56 ± 10 ml/min/mmHg, 64 ± 35 ml/min/mmHg, and 29 ± 9 ml/min/mmHg, respectively, for normal rats, and 27 ± 9 ml/min/mmHg, 42 ± 27 ml/min/mmHg, and 16 ± 7 ml/min/mmHg, respectively, for diseased rats. Lung volumes and gas transfer times for LP ( T trLP ) were 16 ± 2 ml and 22 ± 3 ms, respectively, for normal rats and 12 ± 2 ml and 35 ± 8 ms, respectively, for diseased rats. Xenon diffusing capacities may be useful for measuring changes in gas exchange associated with inflammation and other lung diseases. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.