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Detecting microcirculatory changes in blood oxygen state with steady‐state free precession imaging
Author(s) -
Dharmakumar Rohan,
Qi Xiuling,
Hong Juimiin,
Wright Graham A.
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20911
Subject(s) - precession , steady state (chemistry) , steady state free precession imaging , magnetic resonance imaging , oxygen , nuclear magnetic resonance , microcirculation , medicine , physics , radiology , chemistry , quantum mechanics , astronomy
Recently, it has been demonstrated that oxygen‐weighted images of whole blood can be obtained with steady‐state methods. In this article, based on computational and experimental models, we investigate the potential for employing this technique to monitor oxygen changes in microcirculation. Results show that oxygen‐sensitive images of rabbit kidney and muscle may be obtained at high signal‐to‐noise ratio within a few seconds. The results also show that in steady‐state free precession imaging, in addition to the exchange mechanism that generates oxygen contrast in blood, there are additional mechanisms that provide oxygen‐sensitive contrast in microcirculation. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.