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MR susceptometry for measuring global brain oxygen extraction
Author(s) -
FernándezSeara María A.,
Techawiboonwong Aranee,
Detre John A.,
Wehrli Felix W.
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20892
Subject(s) - oxygen , oxygen saturation , jugular vein , oxygen delivery , saturation (graph theory) , medicine , chemistry , mathematics , organic chemistry , combinatorics
Monitoring of oxygen saturation in jugular venous blood gives an estimate of the balance of global oxygen delivery and cerebral oxygen consumption. We present a noninvasive approach to measure oxygen saturation in vivo in the internal jugular vein using MR susceptometry by exploiting the characteristic susceptibility of deoxyhemoglobin, and demonstrate the feasibility of performing such measurements in a group of subjects. We assessed the sensitivity of the method for detecting small changes in oxygen saturation by monitoring the variations observed during breath‐holding and hypoventilation experiments. Unlike alternative methods, the susceptometric technique does not require calibration. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.