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Measurement of kinetic parameters in skeletal muscle by magnetic resonance imaging with an intravascular agent
Author(s) -
Faranesh Anthony Z.,
Kraitchman Dara L.,
McVeigh Elliot R.
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20884
Subject(s) - skeletal muscle , magnetic resonance imaging , perfusion , nuclear magnetic resonance , intravascular volume status , in vivo , chemistry , biomedical engineering , nuclear medicine , physics , anatomy , medicine , hemodynamics , radiology , biology , microbiology and biotechnology
The purpose of this work was to investigate the use of an intravascular contrast agent to determine perfusion kinetics in skeletal muscle. A two‐compartment kinetic model was used to represent the flux of contrast agent between the intravascular space and extravascular extracellular space (EES). The relationship between the image signal‐to‐noise ratio (SNR) and errors in estimating permeability surface area product ( K trans ), interstitial volume ( v e ), and plasma volume ( v p ) for linear and nonlinear curve‐fitting methods was estimated from Monte Carlo simulations. Similar results were obtained for both methods. For an image SNR of 60, the estimated errors in these parameters were 10%, 22%, and 17%, respectively. In vivo experiments were conducted in rabbits to examine physiological differences between these parameters in the soleus (SOL) and tibialis anterior (TA) muscles in the hind limb. Values for K trans were significantly higher in the SOL (3.2 ± 0.9 vs. 2.0 ± 0.5 × 10 –3 min –1 ), as were values for v p (3.4 ± 0.8 vs. 2.1 ± 0.7%). Differences in v e for the two muscles (8.7 ± 2.2 vs. 8.5 ± 1.6%) were not found to be significant. These results demonstrate that relevant physiological metrics can be calculated in skeletal muscle using MRI with an intravascular contrast agent. Magn Reson Med, 2006. Published 2006 Wiley‐Liss, Inc.