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Quantification of cerebral arterial blood volume using arterial spin labeling with intravoxel incoherent motion‐sensitive gradients
Author(s) -
Kim Tae,
Kim SeongGi
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20867
Subject(s) - intravoxel incoherent motion , arterial spin labeling , cerebral blood flow , cerebral blood volume , nuclear magnetic resonance , chemistry , arterial blood , effective diffusion coefficient , diffusion , nuclear medicine , magnetic resonance imaging , medicine , anesthesia , physics , radiology , thermodynamics
Quantification of cerebral arterial blood volume (CBV a ) is important for understanding vascular regulation. To enable measurement of CBV a with diffusion‐weighted (DW) arterial spin labeling (ASL), a theoretical framework was developed using the effects of intravoxel incoherent motion (IVIM). The pseudo‐diffusion coefficient ( D *) in the IVIM model was evaluated at 9.4 T in DW‐ASL of rat brain under isoflurane anesthesia by variations of both post‐labeling delay ( w ) and magnetization transfer ratio (MTR). D * and its volume fraction decreased at values of w ≥ 0.3 s, and the normalized apparent diffusion coefficient (ADC) increased with MTR, suggesting that D * is closely correlated with CBV a . Thus, the difference between ASL measurements with and without DW gradients is related to CBV a . The CBV a values measured by this approach were compared with values obtained using the modulation of tissue and vessel (MOTIVE) technique with ASL, which varies MT levels without changing spin labeling efficiency. CBV a values from both methods were highly correlated. The measured CBV a values were linearly correlated with cerebral blood flow (CBF) for a PaCO 2 range of 25–50 mmHg; ΔCBV a (ml/100 g) = 0.007 (min −1 ) × ΔCBF (ml/100 g/min). The DW‐ASL approach is simple and easy to implement for human and animal CBV a studies. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.