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New double quantum coherence filter for localized detection of glutathione in vivo
Author(s) -
Zhao Tiejun,
Heberlein Keith,
Jonas Carolyn,
Jones Dean P.,
Hu Xiaoping
Publication year - 2006
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20788
Subject(s) - coherence (philosophical gambling strategy) , glutathione , filter (signal processing) , in vivo , spectroscopy , chemistry , materials science , computer science , optics , nuclear magnetic resonance , physics , mathematics , computer vision , statistics , biology , enzyme , microbiology and biotechnology , quantum mechanics
In this work, a new double quantum filter for glutathione (GSH) editing is introduced, combined with the point‐resolved spectroscopy localization sequence (PRESS), and demonstrated in vivo. Compared to the conventional double quantum coherence filter, the new filter has two major advantages. First, it eliminates the need for calibration scans for optimizing the signal yield, making it more efficient and convenient for routine use. Second, it removes the influence of water saturation pulses on the GSH yield, further improving its accuracy. With this method, GSH concentrations in the left and right parietal lobes of five healthy volunteers were determined to be 0.91 ± 0.16 mM and 0.89 ± 0.16 mM, respectively, in agreement with previous studies. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.