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T 2 † measurement during acute cerebral ischemia by Carr‐Purcell MRI at 4T
Author(s) -
Nikolova Simona,
Hughes Sarah,
Bartha Robert
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20716
Subject(s) - ischemia , nuclear magnetic resonance , magnetic resonance imaging , pulse (music) , lesion , nuclear medicine , susceptibility weighted imaging , pulse sequence , medicine , physics , chemistry , pathology , optics , radiology , detector
Metabolic and structural changes occur in brain tissue within minutes of ischemia. The adiabatic multi‐echo (Carr‐Purcell) localization pulse sequence LASER has shown promise in detecting tissue contrast changes within the first hour of ischemia. The purpose of this initial study was to combine the LASER localization sequence with fast 3D echo‐planar imaging (EPI) to quantify the regional apparent transverse relaxation (T 2 † ) in a rabbit model of acute embolic ischemia at 4 Tesla. Carr‐Purcell T 2 † ‐weighted images were acquired at 7 different echo‐times and used to estimate T 2 † in both cortex and striatum. In ischemic tissue identified by 2,3,5 ‐ triphenyltetrazolium chloride (TTC) staining, the T 2 † increased by approximately 31% after 1 hour of ischemia and remained elevated until study completion at 4 h of ischemia. Lesion volume, defined as the number of pixels with T 2 † greater than 90 ms, increased by 40% between 1 and 4 h after induction of ischemia. Carr‐Purcell LASER‐EPI T 2 † ‐weighted images show promise in detecting early tissue changes in focal cerebral ischemia. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.