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Comparison of X‐ray fluoroscopy and interventional magnetic resonance imaging for the assessment of coronary artery stenoses in swine
Author(s) -
Green Jordin D.,
Omary Reed A.,
Schirf Brian E.,
Tang Richard,
Lu Biao,
Gehl James A.,
Huang J. Jenny,
Carr James C.,
Pereles F. Scott,
Li Debiao
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20699
Subject(s) - medicine , stenosis , radiology , magnetic resonance angiography , fluoroscopy , intraclass correlation , coronary artery disease , magnetic resonance imaging , angiography , catheter , nuclear medicine , clinical psychology , psychometrics
The accuracy of a two‐step interventional MRI protocol to quantify coronary artery disease was compared to the clinical gold standard, X‐ray angiography. Studies were conducted in nine swine with a surgically induced stenosis in the proximal left circumflex coronary artery. The two‐step protocol consisted of catheter‐directed magnetic resonance angiography (MRA), which was first used to localize the stenosis, followed by MRI cross‐sectional images to quantify the degree of stenosis without the use of contrast agent. Line signal intensity profiles were drawn across the vessel diameter at the stenosis site and proximal to the stenosis for each data set to measure percentage stenosis for each animal. Catheter‐directed MRA successfully detected eight of nine stenoses. Cross‐sectional MRI accurately quantified each stenosis, with strong agreement to the measurements made using X‐ray fluoroscopy (intraclass correlation coefficient = 0.955; P < 0.05). This study demonstrates that in the future interventional MRI may be an alternative to X‐ray angiography for the detection and quantification of coronary artery disease. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.