Premium
Detection of the myo ‐inositol 4.06‐ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo
Author(s) -
Choi Changho,
Ogilvie Catherine J.,
Malykhin Nikolai,
Ngo Jennifer T. V.,
Hartfeil Misha A. W.,
Coupland Nicholas J.
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20688
Subject(s) - inositol , nuclear magnetic resonance , proton magnetic resonance , chemistry , creatine , in vivo , cortex (anatomy) , physics , biochemistry , neuroscience , biology , receptor , genetics
A new proton NMR single‐voxel spectral editing strategy for the rapid measurement of myo ‐inositol in human brain is proposed. The spectral editing detects the 4.06‐ppm, weakly coupled resonance by means of selective J rewinding. An 84.6‐ms‐long quadruple‐resonance selective 180° radiofrequency pulse, implemented within an adiabatic‐refocused localization sequence, induces an in‐phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo ‐inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.