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High‐resolution 1 H chemical shift imaging in the monkey visual cortex
Author(s) -
Juchem Christoph,
Logothetis Nikos K.,
Pfeuffer Josef
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20687
Subject(s) - white matter , visual cortex , nuclear magnetic resonance , image resolution , human brain , creatine , high resolution , chemistry , cortex (anatomy) , nuclear medicine , magnetic resonance imaging , neuroscience , physics , optics , biology , medicine , geology , biochemistry , radiology , remote sensing
Functionally distinct anatomic subdivisions of the brain can often be only a few millimeters in one or more dimensions. The study of metabolic differences in such structures by means of localized in vivo MR spectroscopy is therefore challenging, if not impossible. In fact, the spatial resolution of chemical shift imaging (CSI) in humans is typically in the range of centimeters. The aim of the present study was to optimize 1 H CSI in monkeys and demonstrate the feasibility of high spatial resolutions up to 1.4 × 2 × 1.4 mm 3 . The obtained spatial resolution permitted the segregation of gray and white matter in the visual cortex based on the concentration of different metabolites and neurotransmitters like N ‐acetylaspartate, glutamate, and creatine. Concentration ratios of white matter versus gray matter tissue as well as between metabolites matched those reported in the literature from healthy human brain, demonstrating the consistency and reliability of the procedure. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.