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In vivo multiple‐mouse MRI at 7 Tesla
Author(s) -
Bock Nicholas A.,
Nieman Brian J.,
Bishop Johnathan B.,
Mark Henkelman R.
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20683
Subject(s) - scanner , radiofrequency coil , magnetic resonance imaging , imaging phantom , image quality , electromagnetic coil , nuclear magnetic resonance , contrast (vision) , isotropy , radio frequency , distortion (music) , physics , nuclear medicine , biomedical engineering , optics , computer science , medicine , image (mathematics) , radiology , artificial intelligence , telecommunications , amplifier , optoelectronics , cmos , quantum mechanics
We developed a live high‐field multiple‐mouse magnetic resonance imaging method to increase the throughput of imaging studies involving large numbers of mice. Phantom experiments were performed in 7 shielded radiofrequency (RF) coils for concurrent imaging on a 7 Tesla MRI scanner outfitted with multiple transmit and receive channels to confirm uniform signal‐to‐noise ratio and minimal ghost artifacts across images from the different RF coils. Grid phantoms were used to measure image distortion in different positions in the coils. The brains of 7 live mice were imaged in 3D in the RF coil array, and a second array of 16 RF coils was used to 3D image the whole bodies of 16 fixed, contrast agent‐perfused mice. The images of the 7 live mouse brains at 156 μm isotropic resolution and the 16 whole fixed mice at 100 μm isotropic resolution were of high quality and free of artifacts. We have thus shown that multiple‐mouse MRI increases throughput for live and fixed mouse experiments by a factor equaling the number of RF coils in the scanner. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.