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Magnetic resonance imaging‐based spirometry for regional assessment of pulmonary function
Author(s) -
Voorhees Abram,
An Jing,
Berger Kenneth I.,
Goldring Roberta M.,
Chen Qun
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20682
Subject(s) - spirometry , magnetic resonance imaging , lung volumes , displacement (psychology) , lung function , pulmonary function testing , breathing , ventilation (architecture) , biomedical engineering , lung , nuclear medicine , computer science , medicine , radiology , physics , anatomy , psychology , asthma , psychotherapist , thermodynamics
In this work MRI‐based spirometry is presented as a method for noninvasively assessing pulmonary mechanical function on a regional basis. A SPAMM tagging sequence was modified to allow continuous dynamic imaging of the lungs during respiration. A motion‐tracking algorithm was developed to track material regions from time‐resolved grid‐tagged images. Experiments were performed to image the lungs during quiet breathing and volumetric strain was calculated from the measured displacement maps. Regional volume calculations, derived from volumetric strain, were integrated over the entire lung and compared to segmented volume calculations with good agreement. Results from this work demonstrate that MRI spirometry has the potential to become a clinically useful tool for measuring regional ventilation and assessing pulmonary diseases that regionally affect the mechanical function of the lung. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.